Theanticoagulanteffectofheparinisgenerallythoughttobemainlythroughtwoaspects:①inhibitionofthrombin;②InhibitoryeffectoncoagulationactivefactorXa(FXa).Bothofthemdependonthebindingofthepentosestructure
Heparinisaglycosaminoglycan,whichisahighlydispersedsulphatepolysaccharidewithunevenstructure.Lowmolecularweightheparinisdefinedinthefollowingtwoways:1.Heparinwithmolecularweightbetween4000and6500dalto
ThephysicalandchemicalpropertiesHeparinsodiumisawhiteoralmostwhitepowder,tasteless,hydantic,solubleinwater,insolubleinethanol,acetoneandotherorganicsolvents.Ithasastrongnegativechargeinaqueoussolution
HeparinsManufacturerDescribesthepharmacologicaleffectsEnoxparin,asalowmolecularweightheparinpreparation,canmaketheratioofanticoagulantfactorXA/IIAgreaterthan4,soithasastrongantithromboticeffectandacer