Sincethe1930s,heparincanbemainlyusedinclinical,aftermorethan70yearsofclinicalapplicationresearch,peoplehavedevelopedaprofoundunderstandingoftheformationmechanismoftheanticoagulanteffectofheparin,hasbe
Enoxaparinsodium,originallydevelopedbyRhone-PoulencRorerinFrance(latermergedwithHoechstinGermanytoformSanofi),isalowmolecularweightheparinsodiumextractedfrompigintestinemucosa,obtainedbyesterification
Thedilutedmucosawaspumpedintothereactiontankusingacuttingpump,andthephwasadjustedfrom8.3to8.8,andthesalinitywasadjustedfrom4.5to5.3degreesbytheBeaumeter.Heatto55°Candkeepwarmfor2hoursatPH8.3-8.8.Heati
TheManufacturerofheparin-likesubstancesisanatural,synthetic,semi-syntheticsubstancethatactslikeheparin.Alsoknownasguanxinshu,intestinalpolysaccharide.Heparinoidcomplexescanbindtohundredsofproteins,aff
Heparinsodiuminterfereswithmanyaspectsofthecoagulationprocessandhasanticoagulanteffectsbothinvivoandinvitro.Itsmechanismofactioniscomplex,mainlythroughbindingwithantithrombinIII(AT-III),enhancingthela