Heparin sodium interferes with many aspects of the coagulation process and has anticoagulant effects both in vivo and in vitro. Its mechanism of action is complex, mainly through binding with antithrombin III (AT-III), enhancing the latter's inhibitory effect on activated coagulation factors II, IX, X, XI and XII. The consequences include preventing platelet aggregation and destruction, preventing the formation of thrombin activator, preventing prothrombin from becoming thrombin, inhibiting thrombin. This prevents fibrinogen from becoming fibrinogen, which acts as an anticoagulant.For Heparin sodium Price, please visit Kowloon!
1. Prevent thrombosis and embolism, such as deep vein thrombosis, myocardial infarction, pulmonary embolism, thrombophlebitis and postoperative thrombosis.
2. Treat diffuse intravascular coagulation caused by various causes, such as bacterial septicaemia, early separation of placenta, and dissolution of malignant tumor cells caused by diffuse intravascular coagulation, but not by snake bite. Early application may prevent the depletion of fibrinogen and other clotting factors.
3. Other in vitro and in vivo anticoagulant drugs, such as cardiac catheterization, extracorporeal circulation, hemodialysis, etc.
Clinical application of
Intravenous or intramuscular injection: 5000~10000 units/time, once every 4 hours, once every 12 hours.
1. The most common bleeding can occur anywhere.
2. Common allergic reactions such as chills, fever, urticaria, etc.
3. Long-term use of drugs can lead to hair loss, reversible temporary hair loss, osteoporosis and spontaneous fractures.
4. Local irritation, erythema, mild headache, hematoma and ulcer can be seen at the injection site. Intramuscular injections are more serious, so intramuscular injections are not suitable.
5. Short-term thrombocytopenia was observed. Heparin-induced thrombocytopenia (HIT) is caused by the heparin-platelet factor 4 antibody complex binding to the platelet factor 4 receptor. Can activate platelet aggregation, cause arteriole embolism. Although rare, it can be fatal. If HIT occurs, heparin should be discontinued immediately.