Potentialtherapeuticapplications:Anticoagulantandantithromboticactivity:Awell-studiedinteractionofdermatanisthebindingofdermatansulfatetoheparincofactorII,whichactsbyinhibitingtheprocoagulantactivityo
Dermatansulfate,alsoknownaschondroitinsulfateB,isfoundinawiderangeoftissuesandinvirtuallyallanimals.Itisobtainedbybiochemicalextractionandpurification.Dermatansulfateisalinearpolysaccharideformedbydis
PathwaySummaryfromMetaCyc:DermatansulfateisasulfatedglycosaminoglycancomposedofalternatingunitsofsulfatedN-acetyl-α-D-galactosamineandα-L-idopyranuronate(andsomeβ-D-glucuronate)residues.TheN-acetyl
Theroleofdifferentglycosaminoglycanspeciesfromthevesselwallsasphysiologicalantithromboticagentsremainscontroversial.Tofurtherinvestigatethisaspectweextractedglycosaminoglycansfromhumanthoracicaortaand