Protaminecaninhibittheanticoagulanteffectofdheparinsodium.Theprolongationofclottingtimeinducedbythisproductcanbecompletelyneutralized,buttheanti-xaactivityisonlymoderatetoabout25-50%.1mgprotaminecanin
Simultaneoususeofagentsthataffecthemostasis,suchasthrombolyticagents,acetylsalicylicacid,nonsteroidalanti-inflammatoryagents,vitaminKantagonists,anddextran,mayenhancetheanticoagulanteffectofheparinsod
Thelikelihoodofharmfuleffectstothefetusinpregnantwomenisextremelysmall.However,becausethepossibilityofharmfuleffectscannotbecompletelyruledout,itisnotrecommendedforpregnantwomenunlessnecessary.Thereis
Thisproductiscarefullyusedinpatientswiththrombocytopeniaandplateletdeficiency,severeliverandkidneydysfunction,uncontrolledhypertension,hypertensiveordiabeticretinopathy.Recentsurgicalpatientsshouldals