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Dheparin sodium injection drug overdose

  Protamine can inhibit the anticoagulant effect of dheparin sodium. The prolongation of clotting time induced by this product can be completely neutralized, but the anti-xa activity is only moderate to about 25-50%. 1 mg protamine can inhibit the anti-xa effect of 100 IU of heparin sodium (low molecular weight heparin sodium). Protamine itself inhibits initial hemostasis and should only be used in emergency situations.