Heparinsodiumisakindofrarepolymermedicine.Becauseofthespecialsource,itspriceismuchmoreexpensivethanordinarychemicalrawmaterials.Thepriceofheparinsodiumisdeterminedbythepriceofrawsmallintestine.Crudehe
Duetoitsgoodanticoagulanteffect,heparinismainlyusedforsomethrombosisrelateddiseases,suchasdeepveinthrombosis,myocardialinfarction,pulmonaryembolism,peripheralarterythrombosisandbloodhypercoagulability
Heparincrudeproductsindustryisduetotheclinicalvalueofheparinanditssourceislimited,makeitsappearmeans,theonlywayisextractedfromthepigintestine,limitedbythenumberofrawmaterialsandsuppliers,scaleandquali
Heparinsodiumiscrudeheparinsodiumextractedfromthemucosaofthesmallintestineofhealthypigs.Becauseitcontainsalargeamountofprotein,nucleicacid,microorganismandotherimpurities,itneedsphysicalandchemicalext
Thesulfonicandcarboxylicacidsinheparinarehepariniftheyareintheacidifiedform.Thealkalizationofheparinisheparinsodium.NaOHwasaddedtotheheparinsolutionafteralkalization,andbadsolventwasaddedtoprecipitate