Due to its good anticoagulant effect, heparin is mainly used for some thrombosis related diseases, such as deep vein thrombosis, myocardial infarction, pulmonary embolism, peripheral artery thrombosis and blood hypercoagulability caused by various reasons. , mainly to prevent the formation and expansion of thrombosis. However, heparin does have some disadvantages, for example, it carries a risk of bleeding and should be used in a strictly controlled dose. In addition, it may lead to thrombocytopenia, and there is a certain risk of allergies.
Low molecular weight heparin has a lower molecular weight than regular heparin. It can be isolated directly from ordinary heparin or degraded from ordinary heparin. Low molecular weight heparin can selectively inhibit the activity of activated coagulation factor X, but has little effect on thrombin and other coagulation factors. Therefore, compared with ordinary heparin, it has a more accurate targeted inhibition effect.
Compared with ordinary heparin, the clinical application of low molecular weight heparin has the advantages of easy control of anticoagulant determination, small individual differences, generally no monitoring of anticoagulant activity, low toxicity, safety, and long acting time.
Heparin is an antithrombotic drug commonly used in clinic, mainly through indirect inhibition of thrombin activity. In addition to heparin, there are other types of anticoagulants, some of which act directly on thrombin, such as warfarin and hirudin. What kind of anticoagulant should be chosen? Different anticoagulants should be selected according to different situations.