Heparin interferes with many aspects of the blood clotting process and has
an anticoagulant effect on the body. Its effect mechanism is complex, through
first and antithrombin Ⅲ (AT - Ⅲ), and enhance the latter to activate Ⅱ, Ⅸ, X, Ⅺ
and hallooing Ⅻ clotting factors effect, the result involves blocking platelet
aggregation and destruction, inhibit the formation of blood coagulation
activation of enzyme, blocking prothrombin into thrombin, bay thrombin, and
hinder fibrinogen to fibrin, then play anticoagulant effect.
Heparin sodium is a sodium glucosamine sulfate, which is a mixture of molecules with different molecular weights. The molecule has a linear chain structure composed of hexose or ocose repeating units. Disaccharide trisulfate is the primary disaccharide unit of heparin. After complete hydrolysis, D-glucuramine, D-glucuronic acid, L-aduronic acid, acetic acid and sulfuric acid are produced.
1. Heparin combined with the following drugs can aggravate the risk of bleeding: coumarin and its derivatives, aspirin and non-steroidal anti-inflammatory and analgesic drugs, dipyridamole, dextran, adrenocortical hormone, adrenocorticotropic hormone, tissue plasminogen activator, urokinase, streptokinase, etc.
2. Heparin using sodium bicarbonate, sodium lactate and other drugs to correct acidosis can promote the anticoagulant effect of heparin.
3. Mixed injection of heparin and hyaluronidase can not only alleviate myodynia, but also promote heparin absorption. But heparin can suppress the activity of hyaluronidase, so the two should be used in a temporary compatibility, not long after drug mixing.
4. Heparin can interact with insulin receptors and then modify the binding and effect of insulin.
5. Cannot be used in combination with alkaline drugs.
Note: the above content is only for introduction, the use of drugs must be carried out by regular hospitals under the guidance of doctors.