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Discussion on the action mechanism and clinical value of ulinastatin

  In ulinastatin, there are two Kunitz domains with hydrolase inhibitory activity, and the two sugar chains connected with the peptide chain are the sulfated chondroitin sugar chain and an N-linked oligosaccharide, and the gray indicates the sulfated sugar.

  Ulinastatin, also known as urinary trypsin inhibitor, is a kind of glycoprotein from human body, which is involved in the regulation of inflammatory response in blood. It is a kind of innate immune-related substance, which can inhibit the excessive activation of white blood cells, protect the vascular endothelium and basement membrane, and inhibit the increase of vascular permeability. It is clinically used as a therapeutic drug for acute inflammatory response.

  The total content of ulinastatin in the blood is very rich, which mainly exists in the former body form. The inactive precursor has a high molecular weight and weak affinity with proteolytic enzymes. It is not easy to be filtered out into the urine by the kidney, which is the way for the body to store ulinastatin. Free ulinastatin has inhibitory activity on proteolytic enzymes released in various inflammatory reactions, accounting for 2% ~ 10% of the total content.

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