1.Preventthrombosisandembolism,suchasdeepvenousthrombosis,myocardialinfarction,pulmonaryembolism,thrombophlebitisandpostoperativethrombosis.2.Treatmentofdisseminatedintravascularcoagulation(DIC)caused
Heparinsodiuminterfereswithmanypartsofthebloodcoagulationprocessandhasanticoagulanteffectsinandoutofthebody.Itsmechanismiscomplex,mainlythroughandantithrombinⅢ(AT-Ⅲ),andenhancethelattertoactivateⅡ,
PharmacokineticsAbsorption:Thehalf-lifeofFRAGMINhasbeenshowntobe2hoursafterintravenousinjectionand3-4hoursaftersubcutaneousinjection.Thebioavailabilityaftersubcutaneousinjectionisapproximately90%andth
ACTIONANDCLINICALPHARMACOLOGYMechanismofActionFRAGMINisalowmolecularweightheparinwithantithromboticproperties.Dalteparinsodiumisproducedthroughcontrollednitrousaciddepolymerizationofsodiumheparinfromp