Theanticoagulanteffectofheparinisgenerallythoughttobemainlythroughtwoaspects:inhibitionofthrombin;InhibitoryeffectoncoagulationactivefactorXa(FXa).Bothofthemdependonthebindingofthepentosestructureofhe
Relativeto"heparin",thereis"lowmolecularweightheparin","highmolecularweightheparin"iscalled"heparin".Sothequestionis,"What'sthedifferencebetweenhighmolecularheparin,lowmolecularheparin,andheparin?
Heparinsodiumisasodiumsaltofaminoglucansulfateextractedfromtheintestinalmucosaofpigsorcattle.Duetothephysicalandchemicalpropertiesofstrongnegativecharge,heparinsodiumcaninterferewithmanylinksofbloodco
1.HeparinsodiumAPIHeparinsodiumapisaremainlyusedtoproducestandardheparinandlowmolecularweightheparin,andthenlowmolecularweightheparin.Theintermediateofheparinsodiumislowinpurityandcannotbedirectlyused