1, performance differences
Low molecular weight heparin is a kind of low molecular weight heparin prepared by depolymerization of general heparin. Its pharmacodynamics and pharmacokinetic characteristics are different from those of ordinary heparin.
Heparin was first invented from the liver and got its name. It is a mucoglycan sulfate composed of glucosamine, l-aduralglycoside, n-acetylglucosamine and d-glucuronic acid of melon. It has a uniform molecular weight of 15KD and is highly acidic.
2. Different characteristics
Low molecular weight heparin (with good injection absorption, long half-life, high cost of biological benefits, less bleeding, no laboratory monitoring and other benefits, its use in the clinical expansion.
Heparin exists in lung, blood vessel wall, intestinal mucosa and other structures, and is an artificial anticoagulant material in plants. The artificial presence in thin cells was originally extracted mainly from the mucous membranes of cows' lungs or pigs' small intestines.
3. Influence differences
Low molecular weight heparin can be linked with antithrombin ⅲ, resulting in the transformation of the layout of antithrombin ⅲ, thus accelerating the inhibition of factor Xa, resulting in strong anticoagulant results, helping to relieve and aggravate coronary artery lumen occlusion, improving myocardial ischemia state, and it is not easy to eliminate in vivo, and the effect time is long. Platelet performance is rarely affected, and the number of inactivated platelet is not reduced. The effect of coagulation factor Xa on inactivated platelet is strong.
Heparins Manufacturer: As an anticoagulant, heparin is a polymer connected from two polysaccharides produced by melon, each having an anticoagulant effect on the body surface. Clinical mainly used for thromboembolic diseases, myocardial infarction, cardiovascular surgery, cardiac catheter examination, in vitro reincarnation, hemodialysis and so on. With the development of pharmacology and clinical medicine, the use of heparin has been expanding.