(1) Heparin sodium is white or white powder, tasteless, hygroscopic, soluble in water, insoluble in ethanol, acetone and other organic solvents. It has a strong negative charge in aqueous solution and can combine with some cations to form molecular complexes. Aqueous solution is stable at pH 7.
(2) Heparin sodium interferes with many steps of blood coagulation and has anticoagulant effects in vivo and in vitro. Its action mechanism is complex, mainly through antithrombin Ⅲ (AT - Ⅲ), enhance the activation Ⅱ, Ⅸ, Ⅹ, Ⅺ and Ⅻ the inhibitory effect of clotting factors and its consequences involved in preventing platelet aggregation and destruction, inhibit blood coagulation activation of enzyme formation, blocking prothrombin into thrombin, inhibition of thrombin, to prevent fibrinogen into fibrous protein, which play a role of anticoagulant.
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