Ordinary heparin and low molecular weight heparin are two commonly used anticoagulants. Their antithrombotic mechanism is to inhibit the activity of some clotting factors, but there are differences. Check them out with the Heparins Manufacturer.
Heparin, also known as ordinary heparin, is an aminoglycan sulfate extracted from pig intestine mucosa or bovine lung. Unadulterated heparin is a mixture of compounds It interferes with many links in the coagulation process and has anticoagulant effect in vivo and in vitro. It acts on thrombin and factor Xa.
Low molecular weight heparin
Low molecular weight heparin is a kind of low molecular weight heparin prepared by depolymerization of ordinary heparin. Its pharmacodynamics and pharmacokinetic characteristics are not similar to that of ordinary heparin the same. It is a short-chain preparation of ordinary heparin. It exerts its anticoagulant effect by binding to antithrombin III, but not simultaneously binding to thrombin Therefore, the antithrombin iii could not be enhanced and only the anticoagulant factor Xa was retained.
Comparison of ordinary heparin and low molecular weight heparin low molecular weight heparin has the characteristics of strong anti-xa factor and weak antithrombin.
Due to the combination of common heparin with a variety of plasma proteins, the anticoagulant activity is reduced, the bioavailability is low, and the plasma protein concentration combined with common heparin the anticoagulant activity cannot be predicted. APTT should be tested strictly.
Low molecular weight heparin has low binding ability to plasma protein, high bioavailability and predictable anticoagulant activity.
APTT detection is not required with therapeutic doses of low molecular weight heparin. Its half-life is two and four times that of ordinary heparin. High bioavailability and half-life long is the advantage of low molecular weight heparin over regular heparin.
Low molecular weight heparin and ordinary heparin are effective in the treatment of DVT, but they also have some side effects, the most common ones are bleeding and thrombocytopenia.
The anticoagulant action of ordinary heparin is complex, and there are many binding sites with coagulation factors, which affect the number and function of platelets, bleeding and thrombocytopenia are more likely to occur.
Low molecular weight heparin can only bind with antithrombin ⅲ, effectively inhibit thrombosis by inhibiting the activity of Xa clotting factor, and other clotting factors effects are minor, and bleeding and thrombocytopenia are relatively rare.
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