Heparin sodium is an important pharmaceutical raw material used in the production of various drugs. The preparation process and technology of heparin sodium bulk drug are constantly developed and improved to improve product quality and production efficiency. The following are some aspects of preparation technology and technological progress of heparin sodium bulk drug:

　　Improvement of raw materials and formulations: Improvement of raw materials and formulations can improve the quality and yield of heparin sodium apis. For example, the purity and stability of heparin sodium apis can be improved by using new solvents and additives.

　　Improvement of production methods and equipment: The improvement of production methods and equipment can improve production efficiency and reduce production costs. For example, adopting automated production lines can reduce manual errors and improve efficiency.

　　Quality control and quality assurance: Quality control and quality assurance are the key to the preparation of heparin sodium bulk drug. Adopting modern quality control technology and method can ensure the quality and safety of products. For example, spectral analysis, gas chromatography and liquid chromatography can be used to accurately detect the quality and content of products.

　　Environmental protection and sustainable development: Environmental protection and sustainable development are important issues in the pharmaceutical industry today. The preparation process and technology of heparin sodium bulk drug should meet the requirements of environmental protection and sustainable development. For example, the use of waste recovery and reuse technology can reduce pollution and damage to the environment.

　　In conclusion, the development of the preparation process and technology of heparin sodium bulk drug has continuously improved the quality and yield of the product, while meeting the requirements of environmental protection and sustainable development. With the continuous development of science and technology, we believe that the preparation process and technology of heparin sodium bulk drug will continue to progress and innovation, to bring more benefits to people's health and life.