dalteparin api products are commonly used in dapheparin sodium injection, and its indications are as follows: prevention of thromboembolic diseases in surgery; Prevention of deep vein thrombosis and pulmonary embolism; Treatment of existing venous thrombosis; Prevention of thrombus formation during cardiopulmonary bypass during hemodialysis.
Dapheparin sodium is a kind of low molecular weight heparin, the average weight molecular weight is about 5600 ~ 6400 Dalton, AXa/AIIa is about 1.9 ~ 3.2. Compared with standard heparin, low molecular weight heparin has the following advantages: there is no need to monitor thrombin time parameters; Less potential bleeding risk; Low risk of osteoporosis with long-term use; Low risk of thrombocytopenia.
At present, there are ordinary low molecular weight heparin sodium injections on the market in China, whose average weight molecular weight is less than 8000 Da and AXa/AIIa is not less than 1.5. Compared with ordinary low molecular weight heparin sodium, Dapheparin sodium has the following obvious advantages: lower weight average molecular weight, larger AXa/AIIa value, and longer half-life, which make Dapheparin sodium safer and more effective than ordinary low molecular weight heparin sodium.