The anticoagulant mechanism and effect of heparin sodium?

  Heparin sodium is a mucopolysaccharide sulfate alternately composed of glucosamine, L-iduraldehyde side, n-acetylglucosamine and D-glucuronic acid. It has strong anti-coagulation function and can be used in the treatment of various cardiovascular diseases. The main effect was to enhance the anti-thrombin activity in patients and play a certain anti-coagulation effect.

  The anticoagulant mechanism of heparin mainly includes three aspects:

  1. Heparin can enhance the affinity between antithrombin 3 and thrombin, and antithrombin can inactivate thrombin, thus achieving anticoagulant effect. Heparin enhances the action of antithrombin, which is equivalent to further enhancing the anticoagulation function of the human body.

  2. Heparin can inhibit the adhesion and aggregation of platelets, prevent the further formation of thrombosis, and achieve the role of anticoagulation.

The anticoagulant mechanism and effect of heparin sodium?

  3. Heparin can also enhance the activity of protein C, which is an important part of the anticoagulant system and can stimulate vascular endothelial cells to release anticoagulant substances and fibrinolytic substances, which should be paid attention to.

  In addition to its anticoagulant function, heparin also plays an important role in regulating the permeability of blood vessel walls and neovascularization. In addition, studies have shown that heparin has a certain role in regulating blood lipids. Of course, if heparin is not used properly, it may cause bleeding and aggravate the patient's condition, so follow your doctor's advice!