enoxaparin sodium is a low molecular weight heparin sodium sodium obtained from the pig intestinal mucosa by esterification and then by alkali lysis.
The weight average molecular weight of enoxaparin sodium ranged from 3800 to 5000, the weight percentage of oligosaccharides with molecular weight < 2000 was from 12 to 20%, and the weight percentage of oligosaccharides with molecular weight 2000-8000 was from 68 to 82%. The titer of antixa factor per milligram was from 90 to 125IU according to dry products. The ratio of Xa to IIa was between 3.3 and 5.3.
enoxaparin sodium is a low molecular weight heparin that is chemically cleaved from the mother heparin by phenylmethyl ester β-. The active site of Enoxaparin is a unique 1, 6-dehydrated cyclic bicyclic structure, which makes it different from other low molecular weight heparin in pharmacology. Enoxaparin catalyzed the inactivation of coagulation factors IIa, Xa, IXa, XIa, and XIIa by binding to antithrombin III (AT-III), among which, it acted as an anticoagulant primarily by inhibiting Xa.