Heparin sodium was first discovered in the liver and named after it. It is a mucopolysaccharide sulfate alternately composed of glycosamines, glucaldehydes and glucuronic acid, which is strongly acidic. It is also found in lung, blood vessel wall, intestinal mucosa and other tissues, and is a natural anticoagulant substance in animals. As one of the most widely used and effective anticoagulant and antithrombotic drugs in clinical practice, heparin drugs occupy an important position in the international pharmaceutical market, and its market demand is very strong.
The main raw material of heparin drugs is crude heparin, and the main raw material of crude heparin is fresh pig intestinal mucosa. The downstream products are mainly standard heparin preparations or low molecular weight heparin preparations.
Heparin sodium is a mixture of asymmetric molecules with different molecular weights. It is the general name of a class of glucosamine sulfate sodium salts. Heparin sodium hydrolyzed in vivo, some components have the property of prolonging blood coagulation time, so can be used as an anticoagulant, can also be used for anticoagulant treatment of equipment and in vitro tests of blood samples and other in vitro processes. In the aspect of adjuvant therapy, it can be used in the adjuvant treatment of acute myocardial infarction to reduce complications such as thromboembolism.
China has the world's richest raw material resources of heparin, and the output of live pigs accounts for about 50% of the world's total. It has certain advantages in the production of heparin apis. With the gradual elimination of the backward production capacity of upstream heparin, the steady growth of international heparin demand, and the restocking cycle of downstream preparation manufacturers, heparin API has gradually entered a good upward channel.