Heparin sodium can interfere with many aspects of the hemagglutination process and has anticoagulant effects both in vivo and in vitro. Its mechanism is complex, mainly through and antithrombin Ⅲ (AT - Ⅲ), and enhance the latter to activate Ⅱ, Ⅸ, X, Ⅺ and Ⅻ the inhibitory effect of clotting factors and its consequences involved in preventing platelet aggregation and destruction, inhibit the formation of blood coagulation activation of enzyme, blocking prothrombin into thrombin, inhibition of thrombin, thereby preventing fibrinogen to fibrin, So as to play an anticoagulant effect.
Indications for heparin sodium
1. Prevention of thrombosis and embolism, such as deep venous thrombosis, myocardial infarction, pulmonary embolism, thrombophlebitis and postoperative thrombosis, etc.
2. Treat disseminated intravascular coagulation (DIC) caused by various causes, such as bacterial sepsis, early placental dissection, and malignant tumor cell lysis, with the exception of DIC caused by snake bite. Early application prevents depletion of fibrinogen and other clotting factors.
3. Other in vivo and in vitro anticoagulation, such as cardiac catheterization, cardiopulmonary bypass, hemodialysis, etc.
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