Low molecular weight heparin sodium usually refers to low molecular weight heparin sodium, heparin sodium and low molecular weight heparin sodium belong to heparin drugs, from the analysis of drug categories, they belong to the same class of drugs, but there are some differences between them, mainly reflected in theory, clinical application, and safety differences. Therefore, when there are indications for the use of two drugs, they should be used strictly according to the doctor's advice, so as to avoid inappropriate medication and aggravate the disease.
1. Theoretical aspects: heparin sodium belongs to a kind of ordinary heparin, while low molecular weight heparin sodium is a kind of heparin formed by reducing the molecules after further cleavage of ordinary heparin. However, the main purpose of both of them is to be able to anticoagulant and prevent thrombosis.
2. Clinical application: ordinary heparin, also known as heparin sodium, usually has a relatively equal effect on anticoagulation and antithrombosis, and low molecular weight heparin sodium can also be effectively used in anticoagulation, but the antithrombotic effect of this drug is relatively better than that of heparin sodium.
3. Safety: When applying heparin sodium, it is easy to cause more bleeding in patients, such as skin and mucosa bleeding, blood in the stool, and oral wall bleeding when brushing teeth. Therefore, it is necessary to test the coagulation function once every 4-6 hours in the application process, and the dosage of heparin sodium should be adjusted continuously according to the coagulation function. Low molecular weight heparin sodium is more convenient to use, and does not require repeated detection of coagulation. At the same time, the incidence of skin and mucosa bleeding, oral mucosa bleeding, nasal bleeding, urine blood and other bleeding caused by low molecular weight heparin sodium is much lower than that of ordinary heparin sodium.
Use of heparin sodium and low molecular weight heparin sodium should be noted, if allergic to both drugs, should be prohibited. At the same time, the use of heparin sodium and low molecular weight heparin sodium should also be contraindicated for patients with severe hypertension and pancreatic lesions.