Heparin sodium is mainly extracted from pig and sheep small intestinal mucosa and bovine lung. Studies show that heparin sodium is the highest content in pig small intestinal mucosa. Crude heparin sodium is China's traditional export product and occupies an important position in the world.
The extraction process of heparin sodium: raw material treatment - heating enzymatic hydrolysis - cooling adsorption - elution - precipitation - dehydration and drying;
Heparin sodium can interfere with many aspects of the hemagglutination process and has anticoagulant effects both in vivo and in vitro. Mainly through its action mechanism and antithrombin Ⅲ (AT - Ⅲ), and enhance the latter to activate Ⅱ, Ⅸ, X, Ⅺ and Ⅻ the inhibitory effect of clotting factors and its consequences involved in preventing platelet aggregation and destruction, inhibit the formation of blood coagulation activation of enzyme, blocking prothrombin into thrombin, inhibition of thrombin, thereby preventing fibrinogen to fibrin, So as to play an anticoagulant effect.