Heparin is so called because it was first discovered in the liver and is a natural anticoagulant found in many mammalian organs, with the lungs and intestinal mucosa having the highest levels.
Ordinary heparin is a kind of amino glucan sulfate extracted from pig intestinal mucosa or bovine lung. It is a mixture with a molecular weight range of 3000-30000kD, with an average of about 15000KD. The amino glucan sulfate fragments after the cleavage of ordinary heparin, namely low molecular weight heparin calcium heparin, enoxaparin, dalheparin, etc., have an average molecular weight range of 3000-8000KD.
Raw heparin can be obtained by carefully washing fresh pig intestines (or frozen pig intestines after natural thawing) with water, and then going through multiple processes such as enzymatic hydrolysis. The heparin sodium finished product is the crude heparin through dissolution, filtration and other processes to obtain high-quality heparin sodium. Therefore, crude heparin is the raw material, and the finished heparin sodium can be obtained by further refining.