Low molecular weight heparin sodium is a general term for a class of low molecular weight heparin prepared by depolymerization of ordinary heparin. Common low molecular heparin has: Enuo heparin sodium, reach heparin sodium and so on.
The medicinal principle of low molecular weight heparin sodium is factor XA activity, which has little effect on thrombin and other coagulation factors. Its anticoagulation due to the xa activity/antithrombin live line by chemical or enzymatic depolymerization of ordinary heparin, the average molecular weight of about 4 ~ 6kD.
The selective anticoagulant ratio is generally 1.5 ~ 4.0, while
the common heparin is about 1. The lower the molecular weight, the stronger the
anticoagulant factor XA activity, so that the antithrombotic effect and bleeding
effect is separated, maintain the antithrombotic effect of heparin and reduce
the risk of bleeding.
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