Heparin, a common anticoagulant

  Blood coagulation is a complex process of proteolysis involving a series of coagulation factors. Anticoagulant drugs are drugs that prevent blood coagulation by affecting the coagulation factors. Next, xiaobian will introduce heparin, a common anticoagulant.

  Pharmacological effects: Heparin in heparin in vivo and in vitro have a strong anticoagulant effect.

  In vivo process: Heparin is a large molecule with a large amount of negative charge, it is not easy to pass through the biofilm, oral absorption is not, often intravenous administration.

  Mechanism of action: anticoagulation can be achieved by enhancing the activity of antithrombin ⅲ in plasma and accelerating the inactivation of coagulation factors.

Heparin, a common anticoagulant

  Adverse reactions: bleeding (main adverse reactions), thrombocytopenia, osteoporosis, fracture.

  Clinical application:

  (1) Thromboembolic diseases

  (2) Diffuse intravascular coagulation

  (3) Prevention and treatment of myocardial infarction, cerebral infarction, cardiovascular surgery and peripheral venous thrombosis after surgery.

  (4) In vitro anticoagulation: such as cardiac catheterization, extracorporeal circulation and hemodialysis, etc.