Heparin is called heparin because it was first discovered in the liver. It is a mucoglycan sulfate composed alternately of glucosamine, L-aduralside, N-acetylglucosamine and D-glucuronic acid. It has strong anticoagulant function and can be used in the treatment of a variety of cardiovascular diseases.
The anticoagulant mechanism of heparin mainly includes three aspects. First, heparin can enhance the affinity between antithrombin 3 and thrombin, and antithrombin can inactivate thrombin, thus achieving anticoagulation effect. Heparin enhances the action of antithrombin, which is equivalent to further enhancing the body's anticoagulant function. Second, heparin can inhibit platelet adhesion and aggregation, prevent further formation of thrombosis, and achieve anticoagulant effect. Thirdly, heparin can also enhance the activity of protein C, which is an important part of the anticoagulant system and can stimulate the release of anticoagulant and fibrinolytic substances by vascular endothelial cells, which should be paid attention to.
In addition to its anticoagulant function, heparin plays an important role in regulating the permeability of blood vessel walls and angiogenesis. In addition, studies have shown that heparin has a certain role in regulating blood lipid. Of course, if heparin is not used properly, it can also cause bleeding and worsen the patient's condition. So be careful with it.
Through the above brief introduction of the anticoagulant mechanism of heparin, we can know that the reason why heparin can be anticoagulant is to enhance the function of anticoagulant system and fibrinolytic system in human body in essence. Among them, enhancing antithrombin 3 is the key to heparin. In addition, when using heparin, attention should also be paid to assessing the patient's physical condition. Patients at risk of bleeding should use heparin with caution to avoid accidents.