Low molecular weight heparin is a kind of low molecular weight heparin prepared by depolymerization of ordinary heparin. Common low molecular heparin has: enuo heparin sodium, naqu heparin calcium, reach heparin sodium.
Factor ⅹ A activity has little effect on thrombin and other clotting factors. Its anticoagulation is formed by chemical or enzymatic depolymerization of common heparin in the activity of factor ⅹ A/antithrombin. The average molecular weight is about 4 ~ 6kD.
The selective anticoagulant ratio of heparin is generally 1.5 ~ 4.0, while that of ordinary heparin is about 1. The lower the molecular weight is, the stronger the activity of anticoagulant factor ⅹ A is, so that the antithrombotic effect and bleeding effect are separated, the antithrombotic effect of heparin is maintained and the risk of bleeding is reduced.
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