Enoxaparin sodium is a low molecular weight heparin used as an anticoagulant for the prevention and treatment of deep vein thrombosis or pulmonary embolism. Its common name: enoxaparin. Enoxaparin sodium is white or white powder, tasteless, hygroscopic, soluble in water, insoluble in ethanol, acetone and other organic solvents.
Enoxaparin sodium is A low molecular weight heparin preparation, which can make the activity ratio of x factor A to ⅱA greater than 4, so as to exert strong antithrombotic effect and certain thrombolytic effect. There was no significant change in total coagulation index, platelet aggregation time and fibrinogen binding rate at the recommended dose.
Although low molecular weight heparin (LMWH) is suitable for all heparin fragments with molecular weight less than 8000 Da, the effect of each fragment is still dependent on molecular weight. In vitro comparison of enoxaparin sodium (molecular weight 4000~6000 Da) with ordinary heparin showed that the inhibition of thrombin by enoxaparin sodium was about 5 times lower than that by ordinary heparin. In vivo studies also showed that the activated partial thrombin time (APTT) of subcutaneous heparin was significantly longer than that of enoxaparin sodium.
Indications of enoxaparin sodium :1. It is mainly used to prevent venous thrombosis after plastic surgery and general surgery, and coagulation during cardiopulmonary bypass during hemodialysis. 2. Prevention of deep vein thrombosis and pulmonary embolism, and treatment of existing deep vein thrombosis.