Heparin sodium is mainly divided into ordinary heparin sodium, low molecular heparin sodium, heparin derivatives (such as sulfoda sodium), heparin analogues (such as danheparin sodium).
Heparin sodium is a sulphated glucosamine mixture, which is a mucopolysaccharide sulfate composed alternately of D-glucosamine, L-iduronic acid and D-glucuronic acid. It can be prepared from the lungs of cattle or the intestinal mucosa of cattle, sheep and pigs.
Low molecular weight heparin sodium is a short chain preparation obtained by separation or degradation of ordinary heparin sodium. Due to the differences in molecular size, anticoagulant activity, preparation method and manufacturer, the commonly used low molecular weight heparin in clinical practice includes enoxaparin sodium, dapheparin sodium and natriheparin sodium.
Synthesis heparin derivative Sulfonda sodium is a kind of amyl polysaccharide synthesized based on the structure of antithrombin heparin binding site.
Heparin analogues Danheparin sodium sodium is a mixture of sulphated amino glucan, also prepared from pig intestine mucosa, and the main components are heparin sulfate, dermatin sulfate, and chondroitin sulfate. Indana-heparin sodium is rarely used in clinic. The first three drugs are discussed in this paper.
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