Heparin sodium API is the active ingredient of standard heparin preparation and the starting point of low molecular weight heparin production. At present, heparin preparation can only be used by injection in clinical practice, which requires high purity of heparin raw material to ensure the safety of the preparation. In recent years, the demand for heparin raw materials in the international market is very strong, the dosage of heparin preparations is increasing steadily, and the low molecular weight heparin market is expanding rapidly and maintaining a high growth trend. Heparin is one of the most complex compounds in the world and cannot be synthesized in a short time. Currently, only heparin from pig intestine mucosa is available for clinical use.
The raw material for heparin is crude heparin, which can only be extracted from the intestinal mucosa of healthy pigs. Because it contains a large number of impurities, such as impurity protein, nucleic acid and microorganism, it is necessary to obtain heparin with complete natural structural groups through physical and chemical extraction and separation, so as to make heparin API.
Heparin is a mucopolysaccharide widely existing in mammalian tissues, mainly in mast cells, with anticoagulant effect. It is widely used in surgery and the treatment of cerebral thrombosis and myocardial infarction. The molecular weight of heparin is about 3000-37500. Studies of commercial heparin show that there are at least 21 individual molecules. As a natural anticoagulant, it has attracted worldwide attention. It is also one of China's main export drugs.
With the deepening of research, it is found that it not only has anticoagulant, antithrombotic, lipid regulation, but also has anti-inflammatory, anti-allergy, anti-virus, anti-cancer and other effects. At present, it is extracted from pig and sheep intestinal mucosa, bovine lung brine, hair casings and so on. Studies have shown that it is present in high levels in the mucous membranes of pigs' small intestines. Crude oil products are China's traditional export products and occupy an important position in the world.