Heparin Sodium API is a crude Heparin sodium extract from the lining of the small intestine of healthy pigs. Because it contains a large number of protein, nucleic acid, microbial and other impurities. It needs to go through physical and chemical extraction and separation process to get the complete structure of heparin, and then can be made into heparin raw material.
The preparation method of heparin sodium crude product is to clean fresh pig intestines with water carefully, remove the dirt inside and outside and the sefat outside, then grind into chylous, stir, add the same amount of water to mix, add 0.1% preservative to mix well. Then a small amount of dilute lye was used to fine-tune the PH value to 8-9, and then fresh pancreatic juice was added as the enzymolysis agent. Stir and heat to about 40 degrees Celsius for 3-4 hours, then heat to 47-50 degrees Celsius. Add a small amount of porcine pancreatic juice and continue to enzymolize for 4-5 hours. Heparin sodium crude can be obtained by ion exchange adsorption and vacuum drying.
Heparin sodium is an anticoagulant and a mucopolysaccharide substance. It is a sodium salt of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle and sheep. Secreted by mast cells in the body, it occurs naturally in the blood. Heparin sodium can prevent platelet aggregation and injury, inhibit the conversion of fibrinogen to fibrin monomer, inhibit the composition of thrombin and antagonize the formed thrombin, prevent the conversion of prothrombin to thrombin and antagonize thrombin.