1. Excessive use of heparin sodium can cause spontaneous bleeding, which is manifested as mucosal bleeding (hematuria, gastrointestinal bleeding), joint bleeding and wound bleeding, etc. Therefore, clotting time or partial thrombin time (PTT) should be measured during medication. Coagulation time > 30 minutes or PTT>100 seconds indicate overdose. Spontaneous bleeding should be stopped immediately. Severe bleeding can be neutralized by intravenous injection of protamine sulfate with heparin sodium at a rate of no more than 20 mg per minute or 50 mg within 10 minutes. In general, 1 milligram of protamine neutralizes 100 units of heparin in the body.

　　2. If intramuscular or subcutaneous injection is irritating, use a fine needle to inject deep muscle or subcutaneous adipose tissue. Intramuscular injection can cause local hematoma, and 2% procaine hydrochloride solution should be added appropriately.

　　3. It is prohibited for hemorrhagic diseases and various diseases with delayed coagulation. Renal insufficiency animals, pregnant animals, postpartum, abortion, trauma and postoperative animals should be used with caution.

　　4. Blood containing heparin sodium should not be used for similar agglutination, complement and erythrocyte brittleness tests.

　　5. The combination of heparin sodium with sodium bicarbonate and sodium lactate can promote anticoagulation.