Low molecular weight heparin sodium is a kind of low molecular weight aminoglucosan sulfate, which is a new anticoagulant and a short chain heparin preparation composed of a variety of depolymerization groups. It has anticoagulant, anti - thrombotic, anti - inflammatory, anti - tumor and inhibit mesangial cell and matrix proliferation.
The main drugs currently on the market are daparin sodium, enoxaparin sodium and naxion heparin calcium, which are anticoagulant and antithrombotic drugs and are colorless or yellowish clear liquids. Low molecular weight heparin sodium generally refers to the fraction of heparin with molecular weight less than 10000. Compared with standard heparin, LMWH has strong anticoagulant factor XA effect. However, the anticoagulant effect of factor A and thrombin was weak. Therefore, this product has strong antithrombotic effect and less bleeding complications.
In addition, low molecular weight heparin sodium has fibrinolytic activity and can dissolve the formation of fresh thrombi. These drugs have less inhibitory effect on platelet aggregation. It has antithrombotic effect on human body. At the usual dose, there is no significant change in total coagulation parameters, no prolonged bleeding time, little likelihood of thrombocytopenia, and no change in fibrinogen binding. Compared with standard heparin, low molecular weight heparin preparations have higher bioavailability, longer half-life, and faster absorption by subcutaneous injection. Low molecular weight heparin sodium has obvious and lasting antithrombotic activity, and its antithrombotic activity is stronger than anticoagulant activity. Therefore, there is less risk of bleeding when antithrombotic action occurs.
Clinical application :① Prevention of deep vein thrombosis and pulmonary embolism. ② Treatment of acute deep venous thrombosis. ③ Hemodialysis or blood filtration, prevent cardiopulmonary bypass thrombosis or coagulation. ④ Low molecular weight heparin sodium is suitable for the prevention and treatment of postoperative thrombosis.