Heparin sodium is an anticoagulant, a mucopolysaccharide substance, is a sodium salt of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle and sheep. It is secreted by mast cells in the body and occurs naturally in the blood. Heparin sodium can prevent platelet aggregation and destruction, inhibit the conversion of fibrinogen to fibrin monomer, inhibit the formation of thrombin and resist the formation of thrombin, prevent the conversion of prothrombin to thrombin and antithrombin. Heparin sodium can delay or prevent clotting in vivo and in vitro.
The mechanism of action of heparin sodium is extremely complex and affects many links in the blood coagulation process. Its role is:
① Inhibit the formation and function of thrombin, so as to prevent the conversion of prothrombin to thrombin;
② In high concentration, it can inhibit thrombin and other coagulation factors and prevent fibrinogen from becoming fibrin;
③ It can prevent platelet aggregation and destruction.
In addition, the anticoagulant effect of heparin sodium is related to the negatively charged sulfate radical in the molecule. Alkaline substances with positive charge, such as protamine or toluidine blue, can neutralize its negative charge, so it can inhibit its anticoagulation as Chemicalbook. Because heparin can activate and release lipoprotein esterase in the body, hydrolysis of chylomicron triglyceride and low density lipoprotein, it also has hypolipidemic effect. Heparin sodium may be used in the treatment of acute thromboembolic disease, disseminated intravascular coagulation (DIC). Kowloon is Heparin Sodium API Supplier, welcome to consult!