Low molecular weight heparin is a biological agent. The imitation of biological agent is different from the traditional imitation. This suggests that generic products should not be considered to have the same pharmacological activity, efficacy and safety just because they claim to have the same molecular weight, anti-factor Xa or anti-factor Ila activity and/or anti-factor Xa/ anti-LLA ratio as enoxaparin in clinical drug selection. Heparin (including heparin sodium, heparin calcium, and low molecular weight heparin) is an anticoagulant.
heparin sodium classification:
(1) Ordinary (standard) heparin is extracted from the mucous membranes of pigs or sheep with an average molecular weight of 15000 and is quite stable.
(2) Molecular weight less than 6000 is usually called low molecular weight heparin. Compared with ordinary heparin, low molecular weight heparin has a longer half-life, better antithrombotic effect, weaker anticoagulation and bleeding tendency, and has a tendency to replace ordinary heparin.
Heparin sodium Powder Supplier introduces Heparin sodium, enoxaparin sodium, and low molecular weight Heparin calcium.
Low molecular weight heparin sodium and low molecular weight heparin calcium:
1. In the application of low molecular weight heparin, the properties of the two are different. At present, the trend of medical development is liver calcium, which is the processing product of heparin sodium. The safety of heparin application was ensured.
2. The precursor of LMWH is heparin, which is extracted from pig intestines. Heparin is a substance. Enoxaparin, natrol heparin, dapheparin and domestic low molecular weight heparin were obtained by pyrolysis (Corzine's pyrolysis method was not modeled by manufacturing process). Due to different pyrolysis methods, the ratio of anti-XA and anti-IIA is different (the ratio of kersai is 4:1), and the molecular weight obtained is different, resulting in different anticoagulation effects. Therefore, domestic ion separation is not rigorous.
3. In terms of molecular composition, one of the anions of heparin is bound to monovalent sodium ion. The other is bound to divalent calcium ions.