Heparin Sodium API Supplier says Heparin is made from crude Heparin that is extracted from the lining of the small intestine of healthy pigs. Because it contains a large number of protein, nucleic acid, microbial and other impurities, need to go through physical and chemical extraction and separation process, to get a complete structure of heparin, and then make it into heparin raw material.
Crude heparin sodium is the fresh pig intestines carefully cleaned with water to remove internal and external dirt and fat on the skin, and then ground into chylous, stir, add equal amount of water to mix, add 0.1% preservative to mix evenly. Then a small amount of dilute lye was used to fine-tune the PH value to 8-9, and then fresh pancreatic juice was added as the enzymolysis agent. Stir and heat to about 40 degrees Celsius for 3 to 4 hours, then heat to 47 to 50 degrees Celsius. Add a little porcine pancreatic juice and continue to enzymolize for 4 to 5 hours. Crude heparin sodium can be obtained by ion exchange adsorption and vacuum drying.
Heparin sodium is an anticoagulant and mucopolysaccharide substance. It is a sodium salt of glucosamine sulfate extracted from the intestinal mucosa of pigs, cattle and sheep. It is secreted by mast cells in the body and occurs naturally in the blood. Heparin sodium can prevent platelet aggregation and injury, inhibit the conversion of fibrinogen to fibrin monomer, inhibit the composition of thrombin and antagonize the formation of thrombin, prevent the conversion of prothrombin to thrombin and antagonize thrombin.
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