Heparin sodium is a sodium salt of glucosamine sulfate, which is mucopolysaccharide and exerts anticoagulant effects by activating antithrombin iii (AT-). It acts on all three stages of the coagulation process and has anticoagulant effects in vivo and in vitro, prothrombin time and thrombin time can be prolonged. Not absorbed by oral administration, absorbed by subcutaneous, muscular or intravenous administration.
Heparin sodium API Supplier introduces Heparin sodium as a white or nearly white powder, odorless, odorless, hygroscopic, soluble in water, insoluble in ethanol, acetone, dioxane and other organic solvents, activity decreased.
Heparin sodium is a white or almost white powder, tasteless, hygroscopic, soluble in water, insoluble in ethanol, acetone and other organic solvents. Aqueous solution has a strong negative charge and can combine with some cations to form molecular complexes. An aqueous solution is stable at pH 7.
Heparin sodium, together with other mucopolysaccharides, forms a complex arranged in protein junctions, so the preparation of heparin consists of two processes: extraction, dissociation and separation and purification of the heparin protein complex.
Heparin molecules contain sulfate groups and carboxyl groups, which are strongly acidic and polyanions, and can react with cations to form salts. These include metal cations :Ca2+, Na+, K+, organic base long-chain pyridine compounds such as cetylpyridine chloride (CPC), Strychten, basic dye - azuridine A, cationic surfactants (long-chain quaternary ammonium salts) such as cetyltrimethyl ammonium bromide; Cation exchangers and positively charged proteins such as protamine 0 protein. Nitrogen sulfate group in heparin structure is closely related to anticoagulant action. If damaged, its anticoagulant activity is reduced. N-sulfate can activate acid hydrolysis and is stable in alkaline conditions. Anticoagulant activity is also reduced if the free hydroxyl group in the heparin molecule is esterified, such as sulphation, and acetylation does not affect its anticoagulant activity.