Enoxaparin sodium, originally developed by Rhone-Poulenc Rorer in France (later merged with Hoechst in Germany to form Sanofi), is a heparin sodium extracted from pig intestine mucosa, which is esterification to obtain sodium derivative of heparin benzyl ester, and then alkali decomposition to produce low molecular weight heparin sodium. Structurally, it is composed of many complex and uncertain oligosaccharides. At present, most oligosaccharides have 4-enolpyranose acid at the non-reducing end of the sugar chain, and 1, 6-dehydrated structure at the reducing end of the sugar chain, accounting for 15-25% of all sugars.
The weight average molecular weight of enoxaparin sodium was 3800~5000, the weight percentage of oligosaccharides with molecular weight < 2000 was 12~20%, and the weight percentage of oligosaccharides with molecular weight 2000-8000 was 68~82%. The titer of anti-xa factor was 90~125IU per mg, and the ratio of anti-xa to anti-iia was 3.3~5.3.
Enoxaparin sodium is a low molecular weight heparin that is chemically cleaved by the mother heparin after the elimination of methyl benzoate β-. Its active site is a unique 1, 6-dehydrated ring double ring structure, which makes it different from other low molecular weight heparin pharmacological properties. Enoxaparin catalyzed the inactivation of coagulation factors IIa, Xa, IXa, XIa and XIIa by binding with antithrombin III(AT-III), and the anticoagulant effect was mainly exerted by inhibiting Xa.
The effect of low molecular weight heparin on Xa and IIa is mainly related to molecular chain length. Heparin usually has a molecular chain of more than 18 sugar units and can inactivate both IIa and Xa. Most of the molecular chains of low molecular weight heparin are less than 18 sugar units, and it has strong inactivation effect on Xa, but little effect on clotting factor IIa. Therefore, the anti-XA /IIa ratio of enoxaparin sodium with an average molecular weight of 4500Da was 41, which was significantly higher than that of ordinary heparin with an average molecular weight of 15000Da.
Jiulong is a Heparins Manufacturer and Heparin sodium Price.