Blood coagulation is a complex process of proteolysis involving a series of coagulation factors. Anticoagulants are drugs that prevent the blood clotting process by affecting clotting factors. Next, xiaobian will introduce the common heparin sodium anticoagulants.
Heparins Manufacturer describes the pharmacological effects of heparin sodium: it has powerful anticoagulant effects in vivo and in vitro.
In vivo process: Heparin sodium is a large molecule with a large amount of negative charge, it is not easy to pass through the biofilm, oral absorption is not, often intravenous administration.
Mechanism of action: anticoagulation can be achieved by enhancing the activity of antithrombin ⅲ in plasma and accelerating the inactivation of coagulation factors.
Adverse reactions: bleeding (main adverse reactions), thrombocytopenia, osteoporosis, fracture.
Clinical application of Heparin sodium:
(1) Thromboembolic diseases
(2) Diffuse intravascular coagulation
(3) Prevention and treatment of myocardial infarction, cerebral infarction, cardiovascular surgery and peripheral venous thrombosis after surgery.
(4) In vitro anticoagulation: such as cardiac catheterization, extracorporeal circulation and hemodialysis, etc.