Heparin (including the use of heparin sodium, heparin calcium, low molecular weight heparin) is available as an anticoagulant.
Heparins Manufacturer: Manufacturer of heparin
(1) Ordinary (standard) heparin is extracted from pig or sheep mucosa with an average relative molecular weight of 15000, which is quite stable.
(2) Heparin with molecular weight less than 6000 is usually called low molecular weight heparin. Compared with ordinary heparin, low molecular weight heparin has a longer half-life, stronger anticoagulant effect, weaker bleeding tendency, and has a tendency to replace ordinary heparin. In recent years, the clinical commonly used are: heparin sodium (famin), enoxaparin (corzine), low molecular weight heparin calcium (docetaxel, nastrol heparin).
(3) Heparin preparations currently under in-depth study include low anticoagulant activity heparin, recombinant heparin and heparin-like, which have low anticoagulant activity, high antithrombotic activity, long acting time and less bleeding, and have a good application prospect.
Heparin sodium API supplier: Heparin sodium is a sodium salt of glucosamine sulfate extracted from pig intestinal mucosa. It is a mucosaccharide substance that acts as an anticoagulant by activating antithrombin ⅲ (AT- ⅲ). It has an effect on all three stages of the coagulation process, has anticoagulant effect in vivo and in vitro, and can prolong the coagulation time, prothrombin time and thrombin time. It was not absorbed by oral administration, but was well absorbed by subcutaneous, muscular or intravenous administration.
The therapeutic effect of heparin calcium is similar to that of heparin sodium, but this product does not reduce the calcium glia leading to intercellular capillaries and does not change the permeability of blood vessels after subcutaneous injection, which basically overcomes the side effect of easy bleeding caused by subcutaneous injection of heparin sodium. It may also have a marked antirenin and aldosterone activity.