Heparins Manufacturer introduction Heparin (including heparin sodium, heparin calcium and low molecular weight heparin) is an anticoagulant.
Classification of heparin (1) Ordinary (standard) Heparin is extracted from the mucous membranes of pigs or sheep with an average molecular weight of 15000 and is fairly stable.
(2) Low molecular weight heparin (LMWH) is usually defined as heparin with molecular weight less than 6000. Compared with ordinary heparin, low molecular weight heparin has longer half-life, better antithrombotic effect and weaker anticoagulant bleeding tendency. In recent years, the clinical commonly used are: heparin sodium (famin), enoxaparin (corzine), low molecular weight heparin calcium (docetaxel, nastrol heparin).
(3) There are low anticoagulant activity of heparin, modified heparin, heparin, etc. It has the characteristics of low anticoagulant, high antithrombotic, long acting time and less bleeding, and has a great development prospect.
Heparin sodium: Sodium glucosamine sulfate obtained from the intestinal mucosa of pigs. It is a mucopolysaccharide that acts as an anticoagulant by activating antithrombin III (AT-III). It has anticoagulant effect in vivo and in vitro, and can prolong coagulation time, international normalized ratio and thrombin time. Not absorbed by oral administration, well absorbed by subcutaneous, muscular or intravenous administration.
The effect of heparin is similar to that of heparin sodium, but after subcutaneous injection, this product does not reduce calcium colloid in intercellular capillaries, does not change vascular permeability, and basically overcomes the side effects caused by subcutaneous injection of heparin sodium. The product also has obvious anti-renin and anti-aldosterone activities.