Heparin (including heparin sodium, heparin calcium, low molecular weight heparin), are anticoagulants.
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(1) Ordinary (standard) heparin is extracted from pig or sheep mucous membrane and has a fairly stable average molecular weight of 15000.
(2) The molecular weight less than 6000 is usually called low molecular weight heparin. Compared with ordinary heparin, low molecular weight heparin has a longer half-life and a better antithrombotic effect, but a weaker tendency of anticoagulation and bleeding, and has a tendency to replace ordinary heparin. In recent years, the commonly used clinical methods are: dheparin sodium (famanming), enoxaparin sodium (xel), low molecular weight heparin calcium (sudoxide, nadu heparin calcium).
(3) Heparin preparations with low anticoagulant activity, modified heparin and heparin-like are also being studied in depth. These drugs are characterized by low anticoagulant activity, high antithrombotic activity, long action time and little bleeding effect, and have great development prospects.
Heparin sodium: a sodium salt of glucosamine sulfate extracted from the intestinal mucosa of pigs. It is a mucopolysaccharide substance and plays an anticoagulant role by activating antithrombin ⅲ (AT- ⅲ). It has an effect on the three stages of the coagulation process, has an anticoagulant effect in vivo and in vitro, and can prolong the coagulation time, prothrombin time and thrombin time. Oral administration is not absorbed, but subcutaneous, muscular, or intravenous administration is well absorbed.
The effect of heparin calcium and heparin sodium is similar, but the subcutaneous injection of heparin calcium does not reduce the calcium glia of the capillaries between cells, nor does it change the vascular permeability, which basically overcomes the side effect of heparin sodium subcutaneous injection which is easy to cause bleeding. This product also has obvious antirenin and antialdosterone activity. Want to know Heparin sodium price, welcome to consult understand!