Heparin is a polysaccharide biochemical substance extracted from the mucous membrane of the small intestine of pigs. It is called "heparin sodium" because it usually exists in the form of its sodium salt. Heparin has strong anticoagulant and antithrombotic function, and is mainly used in clinical anticoagulant and antithrombotic treatment. It is also the raw material for the production of drugs such as low molecular weight heparin.
Heparins Manufacturer Describes the pharmacological effects of heparin sodium:
Heparin sodium has anticoagulant effect in vivo and in vitro, and can prolong the coagulation time, prothrombin time and thrombin time. It is believed that heparin sodium plays an anticoagulant role by activating antithrombin ⅲ (AT ⅲ). AT ⅲ is a plasma α2 globulin that, as a cofactor of heparin sodium, binds to and inhibits the activity of many coagulation factors. Therefore, many links of coagulation process are affected: ① Inactivated coagulation factors ⅹ ⅱ A, ⅹ ⅰ A, ⅰ ⅹ A, ⅹ A, ⅱ A and ⅷ a; ② Prothrombin complexation (ⅱ A); (3) Neutralizing tissue thrombin (ⅲ). The combination of heparin sodium with AT ⅲ can accelerate the anticoagulant effect of AT ⅲ. Heparin sodium also has a lowering effect on blood lipid in the body, which is due to its activation and release of lipoprotein lipase, which hydrolyzes the triglycerides and low-density lipoprotein of chylomicron. Oral administration does not work and must be administered by injection.
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