In the development of our vasculature additives, there is a very important anticoagulant, which is produced by the mast cells of animal connective tissue through heparin. It is mostly combined with proteins to form a complex. This cultural complex has no anticoagulant activity, but its activity increases with the removal of proteins. Heparin is the compound with the most complex molecular structure known so far in the world. In the short term, it is impossible for enterprises to synthesize it by artificial analytical chemical reaction.
Introduction to Heparins Manufacturer:
Heparin is a white or gray powder, odorless, tasteless, hygroscopic, soluble in water sodium salt, insoluble in ethanol, acetone, dioxane and other organic solvents. It is a mucopolysaccharide sulfate, alternating with glucosamine, edulonamide, N acetylglucosamine, and D glucuronic acid. Its molecular weight is between 1200ー40000, and its antithrombotic and anticoagulant activities are related to its molecular weight.
Heparin has a high negative charge in aqueous solution. It is separated from foreign proteins by saline hydrolysis or enzymatic hydrolysis, and then extracted and purified by ion exchange resin. It is commonly used as strong alkali anion resin or strong alkali anion resin with low cross-linking degree. In the process of ion exchange, the cation in water is exchanged with the hydrogen ion on the cation exchange resin. Anions in water, such as Cl-, HCO3-, heparin, etc. , hydroxyl group exchange with anion exchange resin. So as to achieve the purpose of desalination.
Dissolve the heparin sodium crude product with 15 times 1%NaCl, adjust the pH to about 1.5 with 6Mol/L hydrochloric acid, filter the information to collect the clear solution, adjust the pH and add a hydrogen peroxide, and maintain the pH at 11 at 25 ℃ for 48 hours. After filtration, adjust the pH with the same amount of ethanol through precipitation, the next day with a siphon export out of the social supernatant, precipitation with acetone solution washing cell dehydration, in the dry can be used heparin sodium as a fine. Heparin sodium after the study of ion exchange column can be exchanged between ions, but also can be made heparin lithium or other salts.
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