Plain heparin and low molecular weight heparin
There are two main types of Heparinoid, common heparin (UFH) and low molecular weight heparin (LMWH). The ingredients of the two drugs are actually different, which means their mechanisms of action may be different.
Heparin is an acid mucopolysaccharide extracted and purified from pig intestine mucosa or bovine lung tissue. It is a mixture of aminoglycosides. Its molecular weight span is relatively large, ranging from 3000 D to 35,000 D, which also determines its outstanding anticoagulation effect.
Low molecular weight heparin is obtained by enzymatic hydrolysis or chemical reaction degradation ability of ordinary heparin. The molecular weight is relatively simple, relatively small, and the comparative studies are concentrated, between 1000-10000 D, and the purity requirement is relatively high compared with enterprises.
Metabolism and elimination of Heparinoid drugs
The metabolism and elimination of drugs are also related to their efficacy.
Ordinary heparin can be combined with a variety of proteins, and when combined with endothelial cell technology, it is effectively cleared by the reticuloendothelial system, and part of it is excreted by the kidneys. Therefore, for patients with renal insufficiency, we can choose to use some common heparin, because it is only metabolized by some students who are studying kidney problems.
Low molecular weight heparin has small molecular weight, low affinity, and small neutralization with PF4 and protamine. It is mainly metabolized through kidney, which limits the application of low molecular weight heparin in patients with renal insufficiency.
Due to their high molecular weight, Heparinoid drugs cannot pass through the pleura, peritoneum and placental tissues, so they can be used in pregnancy because they are relatively safe, do not easily pass through the placenta and have little impact on the fetus.