Anticoagulation principle of heparin sodium

  1. Inhibit the formation of part of thrombin into kinase :(enhanced the activity of antithrombin Ⅲ and several hundred times) Heparin binds to antithrombin fraction (AT-I) to form molecular heparin AT-I complex. AT-Ⅲ is an inactivation of factors such as XLA, XLA and XA that have the activity of serine as a protease tissue inhibitor.

  2. Thrombin interference: when low dose heparin binds to AT-III, the active site of AT-III (arginine residue) is more likely to bind to the active center of thrombin (serine residue), forming a stable thrombin - antithrombin complex, thus inactivating thrombin and inhibiting the conversion of fibrinogen into fibrin.

  3. Interfering thrombin activation factor III, affecting the formation of insoluble fibrin, and preventing thrombin from normally activating factor VIII and factor V.

  4. Prevent platelet aggregation and destruction: Heparin can prevent platelet adhesion and enterprise aggregation in patients, so as to prevent the release due to platelet prolysis as well as platelet factor 3 and 5-hydroxytryptamine. The anticoagulant effect of heparin is related to the concentration of sulfate group with strong negative charge in related molecules. When the sulphuric acid reaction group is hydrolyzed or neutralized by protamine with a strong positive charge, the anticoagulant activity is rapidly lost.

  Heparins Manufacturer reminds you that sodium heparin interferes with multiple stages of the blood coagulation process and has an anticoagulant effect in vivo and in vitro. The consequences include preventing platelet clotting and destruction, blocking the formation of coagulation-activase, preventing thrombin from becoming thrombin, inhibiting thrombin, and thus preventing cellulose from becoming fibrin and thus acting as an anticoagulant.

  And with the following basic drug heparin can share, can increase patients bleeding risk: coumarin and its derivatives, aspirin and non-steroidal anti-inflammatory analgesic, dipyridamole, dextran and adrenal cortex and hormone, cortex hormone ACTH cells, the original organization fibrinolytic enzyme activation, urokinase, streptokinase. Heparin combined with actual sodium bicarbonate and sodium lactate to correct the presence of acidosis can promote the use of heparin anticoagulant effect.

  Heparin and hyaluronidase combined injection can not only relieve the pain of intramuscular injection, but also promote the absorption of heparin. But heparin can inhibit the activity of hyaluronidase, so the two drugs should be used temporarily, and should not be stored for a long time after mixing. Heparin can interact with insulin receptors to alter the binding and action of insulin and should not be used with alkaline drugs. If you want to know about Heparin Sodium Price, please come to consult.