Heparin (including heparin sodium, heparin calcium, low molecular weight heparin), are anticoagulant drugs.
Classification of heparin
(1) Ordinary (standard) heparin is extracted from pig or sheep mucous membrane with an average molecular weight of 15000, which is quite stable.
(2) The molecular weight less than 6000 is usually called low molecular weight heparin. Compared with ordinary heparin, low molecular weight heparin has a longer half-life and better antithrombotic effect, but has a weaker anticoagulant bleeding tendency and has a tendency to replace ordinary heparin. Clinical commonly used in recent years are: daheparin sodium (faanming), enoxaparin sodium (kesai), low molecular weight heparin calcium (kespin, naqu heparin calcium).
(3) There are other heparin preparations with low anticoagulant activity, modified heparin and heparin-like substances that are currently under in-depth study. These drugs are characterized by low anticoagulant activity, high antithrombotic activity, long acting time and less bleeding effect, which have great development prospects.
Heparins Manufacturer describes the pharmacological effects of heparin:
① Enhance the affinity between antithrombin 3 and thrombin, accelerate the inactivation of thrombin;
② Inhibit platelet adhesion aggregation;
③ Enhance the activity of protein C and stimulate the release of anticoagulant and fibrinolytic substances by vascular endothelial cells.
2.inhibit platelets, increase the permeability of vascular wall, and regulate angiogenesis.
3. It has the effect of regulating blood lipid.
4. It can act on multiple links of complement system to inhibit system overactivation. Related to this, heparin also has anti-inflammatory, anti-allergic effects.