Relative to "heparin", there is "low molecular weight heparin", "high molecular weight heparin" is called "heparin". So the question is, "What's the difference between high molecular heparin, low molecular heparin, and heparin?"
Heparins Manufacturer distinguishes low-molecular-weight heparin from heparin in three ways:
1. Characteristics of low molecular weight heparin and heparin are different: the incidence of low platelet count is lower than that of heparin; the ratio of activity to anticoagulant activity of low molecular weight heparin is 2-4, and that of ordinary heparin is 1; the bleeding rate is lower than that of heparin; patients with renal insufficiency still need to monitor activated partial thrombin time; and the incidence of osteoporosis is lower than that of heparin.
2. The composition of the two is different: low molecular weight heparin is the general name of a class of low molecular weight heparin prepared by depolymerization of ordinary heparin. Heparin was first found in the liver and got its name. It is a mucoglycan sulfate composed alternately of glucosamine, l-aduralside, n-acetylglucosamine and d-glucuronic acid, with an average molecular weight of 15KD and strong acid.
3. Pharmacokinetics of low molecular weight heparin and low molecular weight heparin were different: anticoagulant factor Xa activity t1/2. It was significantly longer than ordinary heparin, and t1/2 in vivo was about 8 times that of ordinary heparin, and bioavailability of anticoagulant factor Xa activity was 3 times that of ordinary heparin. The bioavailability of subcutaneous administration was almost 100% after 12h of intravenous administration. Once per day, easy to use.
Heparin is not absorbed orally, but is well absorbed by subcutaneous, muscular or intravenous injection. After absorption, heparin is distributed in blood cells and plasma, and part of heparin can diffuse to extravascular tissue space. After intravenous injection, it can be highly combined with plasma low density lipoprotein to form complex, and can also be combined with globulin and fibrinogen, absorbed by mononuclear phagocyte system into liver metabolism, and partially decomposed into urine heparin by heparin in the liver.