Heparin sodium is a sodium salt of amino glucan sulfate extracted from the intestinal mucosa of pigs or cattle. Due to the physical and chemical properties of strong negative charge, heparin sodium can interfere with many links of blood coagulation process, and has anticoagulant effect in vivo and in vitro. Its mechanism of action is complicated, mainly through binding with antithrombin ⅲ (AT- ⅲ), and enhancing the inhibition of antithrombin ⅲ on activated ⅱ, ⅸ, ⅹ, ⅺ and ⅻ coagulation factors. Can prevent platelet aggregation and destruction, hinder the formation of coagulation-activating enzyme; Prevent prothrombin from becoming thrombin; Inhibit thrombin, thereby preventing fibrinogen to fibrin, to achieve the role of anticoagulation.
The Heparins Manufacturer describes the sulfonic and carboxylic acids in heparin as the acid form. The alkalization of heparin is heparin sodium.
NaOH was added to the heparin solution after alkalization, and bad solvent was added to precipitate the heparin sodium.
Heparin sodium was acidified by strong acid and precipitated by bad solvent.
The anticoagulant effect of heparin is effective in the acidified state. But heparin is easily deactivated. Therefore, heparin sodium should be used for normal storage.